Hanyin Wang

Internal Medicine Physician · Computer Science PhD Student at UIUC

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I am an Internal Medicine Physician at Mayo Clinic Health System and a Computer Science PhD candidate at the University of Illinois Urbana-Champaign. I am fortunate to be advised by Prof. Jimeng Sun. Before this, I received my MD degree and completed my residency training in Internal Medicine.

I am passionate about developing large language models for healthcare applications, with a focus on addressing real-world clinical challenges that have measurable impact. My particular interests include clinical note generation and reinforcement learning. Additionally, I am actively exploring startup opportunities to translate these research advancements into practical healthcare solutions.

Selected Publications & Preprints (Google Scholar)

  • Process-Supervised Reward Models for Clinical Note Generation: A Scalable Approach Guided by Domain Expertise
    arXiv preprint arXiv:2412.12583
    Hanyin Wang, Qiping Xu, Bolun Liu, Guleid Hussein, Hariprasad Korsapati, Mohamad El Labban, Kingsley Iheasirim, Mohamed Hassan, Gokhan Anil, Brian Bartlett, et al.
    [paper]

  • A perspective for adapting generalist ai to specialized medical ai applications and their challenges
    arXiv preprint arXiv:2411.00024
    Zifeng Wang, Hanyin Wang, Benjamin Danek, Ying Li, Christina Mack, Hoifung Poon, Yajun Wang, Pranav Rajpurkar, Jimeng Sun
    [paper]

  • Towards Adapting Open-Source Large Language Models for Expert-Level Clinical Note Generation
    ACL 2025 Findings
    Hanyin Wang, Chufan Gao, Bolun Liu, Qiping Xu, Guleid Hussein, Mohamad El Labban, Kingsley Iheasirim, Hariprasad Korsapati, Jimeng Sun
    [paper]

  • DRG-LLaMA: tuning LLaMA model to predict diagnosis-related group for hospitalized patients
    npj Digital Medicine 2024
    Hanyin Wang, Chufan Gao, Christopher Dantona, Bryan Hull, Jimeng Sun
    [paper]

  • A Reflection and Outlook on Clinical Adaption of Large Language Models
    AAAI 2024 Spring Symposium on Clinical Foundation Models
    Hanyin Wang, Chufan Gao, Jimeng Sun
    [paper]

  • Clonal dynamics of Richter transformation in chronic lymphocytic leukemia
    Hematological oncology 2024
    Hanyin Wang, Shulan Tian, Charla R Secreto, Sutapa Sinha, Min Shi, Timothy Call, Yucai Wang, Sameer A Parikh, Saad S Kenderian, Rong He, et al.
    [paper]

  • Differential transcriptomic profiling in ibrutinib-naïve versus ibrutinib-resistant Richter syndrome
    Hematological Oncology 2022
    Hanyin Wang, Shulan Tian, Qing Zhao, Wendy Blumenschein, Jennifer H Yearley, Charla R Secreto, Sutapa Sinha, Timothy G Call, Yucai Wang, Sameer A Parikh, et al.
    [paper]

  • Unexpected BP sensitivity to angiotensin II in a patient with coronavirus disease 2019, ARDS, and septic shock
    Chest 2020
    Hanyin Wang, Subhraleena Das, Patrick M Wieruszewski, Jamil Taji, Brian Bartlett, Nabila Azad, Arnab Chowdhury, Gururaj J Kolar, Nitesh Jain, Mir R Subla, et al.
    [paper]

Clinical Experience

  • Mayo Clinic Health System, Mankato, MN, USA
    Co-Director - AI Validation and Stewardship Program (2024 - Present)
    Associate Chief Medical Information Officer (2023 - Present)
    Chair - Department of Hospital Internal Medicine (2021 - 2024)
    Hospitalist Physician (2018 - Present)

  • Tufts Medical Center, Boston, MA, USA
    Resident Physician, Internal Medicine
    2015 - 2018